This video compares the original 4:3 aspect ratio of the Resident Evil Remake to the 16:9 widescreen aspect ratio. You can check out the footage, which shows off the beginning of the game, below:
As you can probably see, the screen is cut off on the top and bottom side if you play the game on widescreen.
While the game is still perfectly playable, you won’t be able to see everything like you would if you use the original 4:3 aspect ratio.