This Seeking Tech article will show you how to find all five safes, and how you can unlock them, in Resident Evil Requiem. By opening every one, you should unlock the No Safe is Safe trophy and achievement.
You can find the locations and combinations in the text and video guides below:
Bar and Lounge:
- For Casual & Standard Difficulty: Left 10, Right 80 and Left 30
- For Insanity Difficulty: Right 20, Left 50 and Right 30
Examination Room:
- For Casual & Standard Difficulty: Left 30, Right 10 and Left 50
- For Insanity Difficulty: Right 50, Left 30 and Right 90
Care Center Basement:
- For Casual & Standard Difficulty: Right 60, Left 40 and Right 80
- For Insanity Difficulty: Left 70, Right 50 and Left 20
Sterilization Chamber:
- For Casual & Standard Difficulty: Right 10, Left 90 and Right 20
- For Insanity Difficulty: Left 80, Right 50 and Left 0
Monitor Control Room:
- For Casual & Standard Difficulty: Left 50, Right 60 and Left 80
- For Insanity Difficulty: Right 20, Left 0 and Right 70