This Seeking Tech guide will explain how you can quickly beat the Mega Glooper in Astro Bot. Use the following video as a reference:
To start the fight, suck up the garbage on the sand. You will be able to move on rails by tilting your controller.
When the Glooper shows up, aim your suction directly at it. When he starts to shoot spikes, you should focus on finding an opening to safely avoid his attack. Otherwise, keep your suctioning on the Glooper to quickly end the fight.