You may find aiming in the virtual reality mode of the Resident Evil 4 Remake to be somewhat difficult. To make it easier, you can check out this Seeking Tech guide to see how you can enable laser sight for all weapons.
1. Start off by opening the Options menu in the virtual reality mode.
2. Next, you need to select the VR Settings tab at the top to switch over to it.
3. You should find the Laser Sight Assist setting. It should have the following description:
Turn the functionality that applies a laser sight to all weapons on/off.
4. Make sure that the Laser Sight Assist setting is set to “On” and then exit the Options menu.
5. When you return to the game, you should now see a laser sight when aiming your weapon.